Nakagawa S, Kojima M, Takada H, Sugimoto K, Mikami K, Watanabe H
Department of Urology, Kyoto Prefectural University of Medicine, Japan.
Gan To Kagaku Ryoho. 1992 Sep;19(11):1873-7.
From our experimental study, an instillation of THP for 5 minutes was attempted in 23 patients with superficial bladder tumors. THP (30 mg dissolved in 50 ml of distilled water) was instilled into the bladder 6 times every 48 hours. Of 23 patients, 9 (39%) showed complete disappearance of the bladder tumors, while partial disappearance (more than 50% tumor reduction) was observed in 3 cases (13%). Therefore the overall response rate was 52%. Neither urinary frequency nor hematuria was observed in all the cases, while painful urination was observed in 3 cases (13%). This newly designed bladder instillation therapy was effective against superficial bladder tumors with low incidence of local side effects.
在我们的实验研究中，对23例浅表性膀胱肿瘤患者尝试进行了5分钟的吡柔比星灌注。将吡柔比星（30毫克溶解于50毫升蒸馏水中）每48小时向膀胱内灌注6次。23例患者中，9例（39%）膀胱肿瘤完全消失，3例（13%）观察到部分消失（肿瘤缩小超过50%）。因此，总有效率为52%。所有病例均未观察到尿频和血尿，3例（13%）观察到尿痛。这种新设计的膀胱灌注疗法对浅表性膀胱肿瘤有效，且局部副作用发生率低。
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