Masuda H, Hirose J, Suzuki K, Tajima A, Aso Y
Gan To Kagaku Ryoho. 1986 Jul;13(7):2411-4.
The effect of (2"R)-4'-0-tetrahydropyranyladriamycin (THP), a derivative of adriamycin (ADM) on bladder tumors was evaluated by intravesical instillation. Twenty-one patients with bladder tumors were treated with THP instillation into the bladder. THP (20-30 mg dissolved in 20-40 ml of distilled water) was instilled into the bladder daily for 3 consecutive days as a course. The patients received 2 to 5 courses in total. Of 21 patients, 4 showed complete disappearance of the bladder tumors, while partial response (50% tumor reduction) was observed in 6 cases. Therefore, the overall response rate was 48%. However, with regard to the 16 patients with superficial bladder tumors (Ta, T1) an overall response rate of 63% was noted. The main side effect of THP instillation was temporary bladder irritability, which was seen in 57% of all the patients. No cases revealed systemic side effects. The same antitumor effect was obtained at a lower concentration of THP in the intravesical chemotherapy, compared with that of ADM. It was concluded that THP is a useful drug for the intravesical chemotherapy of bladder tumors.
通过膀胱内灌注评估阿霉素（ADM）衍生物（2“R）-4'-0-四氢吡喃基阿霉素（THP）对膀胱肿瘤的作用。21例膀胱肿瘤患者接受了THP膀胱灌注治疗。将THP（20 - 30mg溶于20 - 40ml蒸馏水中）连续3天每日灌注膀胱作为一个疗程。患者总共接受2至5个疗程。21例患者中，4例膀胱肿瘤完全消失，6例观察到部分缓解（肿瘤缩小50%）。因此，总缓解率为48%。然而，对于16例浅表性膀胱肿瘤（Ta、T1）患者，总缓解率为63%。THP灌注的主要副作用是暂时性膀胱刺激征，见于所有患者中的57%。未发现全身副作用。与ADM相比，在膀胱内化疗中较低浓度的THP即可获得相同的抗肿瘤效果。结论是THP是膀胱肿瘤膀胱内化疗的一种有用药物。
