Lin Yan-ping, Zhou Rui-xiang, Guo Shi-ming
Faculty of Orthopedics and Traumatology, Fujian College of TCM, Fuzhou 350003.
Zhongguo Zhong Xi Yi Jie He Za Zhi. 2004 May;24(5):431-4.
To study the effect of Jiangu granule (JGG) on quality of bone in model rats with osteoporosis.
Osteoporosis model was established by means of ovariectomy. Bone mineral density (BMD) was measured with dual energy X-ray densitometry. Osseous tissue structure of upper tibia was observed by ono-decalcified section and toluidine blue staining, and morphometry was carried out. Compressive strength limit and elastic modulus of first lumbar vertebrae, and bend load of femur were measured by light-based elastometer.
JGG can significantly increase BMD, area of trabecula and thickness of bone cortex/diameter of marrow cavity ratio of model rats, to elevate the compressive strength limit of vertebrae and bend load of femur.
JGG could increase BMD of osteoporosis model rats, and also could effectively improve the structure of osseous tissue, biomechanical property of bone and enhance the overall quality of bone.
研究健骨颗粒（JGG）对骨质疏松模型大鼠骨质量的影响。
采用卵巢切除法建立骨质疏松模型。用双能X线骨密度仪测量骨密度（BMD）。通过不脱钙切片和甲苯胺蓝染色观察胫骨上段骨组织结构，并进行形态计量学分析。用基于光的弹性仪测量第一腰椎的抗压强度极限和弹性模量以及股骨的弯曲载荷。
健骨颗粒可显著提高模型大鼠的骨密度、小梁面积和骨皮质厚度/骨髓腔直径比值，提高椎体的抗压强度极限和股骨的弯曲载荷。
健骨颗粒可增加骨质疏松模型大鼠的骨密度，有效改善骨组织结构、骨生物力学性能，提高骨的整体质量。
