齐多夫定（AZT）和司他夫定（d4T）同二聚体及异二聚体的化学酶促合成及其抗HIV活性评估。
Chemoenzymatic syntheses of homo- and heterodimers of AZT and d4T, and evaluation of their anti-HIV activity.
作者信息
Taourirte M, Mohamed L Ait, Rochdi A, Vasseur J J, Fernández S, Ferrero M, Gotor V, Pannecouque C, De Clercq E, Lazrek H B
机构信息
Faculty of Sciences and Techniques Gueliz, Marrakesh, Morocco.
出版信息
Nucleosides Nucleotides Nucleic Acids. 2004;23(4):701-14. doi: 10.1081/NCN-120037749.
PMID:15200032
Abstract
Homo- and heterodimers of AZT and d4T, possessing carbonate and carbamate linkers, have been synthesized with the aim to enhance the antiviral activity of their components. Homo- and heterodimer carbamates showed weak anti-HIV activity. On the other hand, dinucleoside carbonates showed marked antiviral activity.
摘要
已合成具有碳酸酯和氨基甲酸酯连接基的齐多夫定（AZT）和司他夫定（d4T）的同二聚体和异二聚体，目的是增强其组分的抗病毒活性。同二聚体和异二聚体氨基甲酸酯显示出较弱的抗HIV活性。另一方面，二核苷碳酸酯显示出显著的抗病毒活性。
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