Zifko Udo A
Klinik Pirawarth, Neurological Rehabilitation Centre, Kurhausstrasse 100, A-2222 Bad Pirawarth, Austria.
Drugs. 2004;64(12):1295-304. doi: 10.2165/00003495-200464120-00003.
As long as no causal treatment is available for multiple sclerosis (MS), and as long as only some patients with MS respond to immunomodulators, symptomatic treatment is of paramount importance. Fatigue is the most common symptom of MS and is associated with a reduced quality of life. It is described as the worst symptom of their disease by 50-60% of patients. The first step in managing MS-related fatigue is identifying and eliminating any secondary causes. Primary fatigue syndrome can be alleviated with drug treatment in many cases. Modafinil has been shown to be effective in some studies, and amantadine is an alternative for patients who do not respond to or cannot tolerate modafinil. The nonpharmacological management of fatigue in MS includes inpatient rehabilitation and aerobic endurance exercise. This article describes the pathophysiology, diagnosis and treatment of MS-related fatigue--the most common symptom of MS.
只要尚无针对多发性硬化症（MS）的病因治疗方法，并且只要只有部分MS患者对免疫调节剂有反应，对症治疗就至关重要。疲劳是MS最常见的症状，与生活质量下降有关。50%-60%的患者将其描述为疾病最严重的症状。管理与MS相关疲劳的第一步是识别并消除任何继发原因。在许多情况下，原发性疲劳综合征可通过药物治疗得到缓解。在一些研究中，莫达非尼已被证明有效，而金刚烷胺是对莫达非尼无反应或不能耐受的患者的替代药物。MS疲劳的非药物管理包括住院康复和有氧耐力运动。本文描述了与MS相关疲劳（MS最常见的症状）的病理生理学、诊断和治疗。
