Zifko Udo A
Sonderkrankenanstalt für Neurologie, Klinik Pirawarth, Kurhausstrasse 100, A-2222 Bad Pirawarth.
Wien Med Wochenschr. 2003;153(3-4):65-72. doi: 10.1046/j.1563-258x.2003.02014.x.
Fatigue is the most common symptom of multiple sclerosis. 75%-90% of patients with multiple sclerosis report having fatigue, and 50%-60% describe it as the worst symptom of their disease. Fatigue is significantly associated with reduced quality of life and is also a major reason for unemployment, especially for patients with otherwise minor disability. The mechanisms underlying abnormal levels of fatigue in multiple sclerosis are poorly understood. To date, drug treatment has been only partially successful in alleviating fatigue, and effects vary widely from patient to patient. Amantadine and modafinil showed to be effective in the treatment of fatigue in some studies. Non-pharmacological management of fatigue in multiple sclerosis includes inpatient rehabilitation and endurance training. There is also evidence, that pulsing electromagnetic fields may improve fatigue associated with multiple sclerosis. This paper summarizes the recent literature on pathophysiology, diagnosis and therapy of the most common symptom of multiple sclerosis.
疲劳是多发性硬化症最常见的症状。75% - 90%的多发性硬化症患者报告有疲劳症状，50% - 60%的患者将其描述为疾病最严重的症状。疲劳与生活质量下降显著相关，也是失业的主要原因，尤其是对于其他方面只有轻微残疾的患者。多发性硬化症中疲劳水平异常的潜在机制尚不清楚。迄今为止，药物治疗在缓解疲劳方面仅取得部分成功，而且患者之间的效果差异很大。在一些研究中，金刚烷胺和莫达非尼显示对治疗疲劳有效。多发性硬化症疲劳的非药物管理包括住院康复和耐力训练。也有证据表明，脉冲电磁场可能改善与多发性硬化症相关的疲劳。本文总结了关于多发性硬化症最常见症状的病理生理学、诊断和治疗的最新文献。
