Jiang Wen G, Watkins Gareth, Douglas-Jones Anthony, Mansel Robert E
Metastasis Research Group, University of Wales College of Medicine, Cardiff, UK.
Int J Oncol. 2004 Jul;25(1):81-5.
Psoriasin (S100A7) is a member of the S100 gene family that is involved in psoriasis, which can be induced in cultured squamous epithelial cells. Previously, this molecule has been shown to be over-expressed in human ductal carcinoma in situ and invasive breast cancers. This current study examine the levels of expression of this molecule in a group of human breast tumours, with particular emphasis on the relationship with the clinical outcomes using quantitative PCR and the distribution in tumours using immunohistochemistry. Psoriasin is primarily expressed in breast cancer cells, and at very low level in normal breast epithelial cells. Quantitative analysis of psoriasin mRNA has shown that breast tumour tissues exhibited a significantly high level of psoriasin compared with normal tissues (p=0.0026). The levels do not correlate with nodal status of breast tumours, however levels in grade 2 and grade 3 tumours were significantly higher compared with that in grade 1 tumours (p=0.07 and p=0.0015, vs grade 1 respectively). Lobular carcinoma also had higher levels of psoriasin compared with ductal tumours. The most interesting observation is that levels of psoriasin were significantly higher in patients who developed metastatic disease and in patients who died of breast cancer (p=0.02 and p<0.001, vs disease-free, respectively). It is concluded that aberrant expression of psoriasin is commonly seen in human breast cancer and that excessively high levels are correlated with the clinical outcomes.
银屑素（S100A7）是S100基因家族的成员，与银屑病有关，可在培养的鳞状上皮细胞中诱导产生。此前，该分子已被证明在人导管原位癌和浸润性乳腺癌中过度表达。本研究使用定量PCR检测了一组人类乳腺肿瘤中该分子的表达水平，特别关注其与临床结局的关系，并使用免疫组织化学检测了其在肿瘤中的分布。银屑素主要在乳腺癌细胞中表达，在正常乳腺上皮细胞中表达水平很低。银屑素mRNA的定量分析表明，与正常组织相比，乳腺肿瘤组织中银屑素水平显著升高（p = 0.0026）。该水平与乳腺肿瘤的淋巴结状态无关，然而，2级和3级肿瘤中的水平分别与1级肿瘤相比显著更高（p = 0.07和p = 0.0015，与1级相比）。小叶癌中的银屑素水平也高于导管癌。最有趣的观察结果是，发生转移的患者和死于乳腺癌的患者中银屑素水平显著更高（分别与无病患者相比，p = 0.02和p < 0.001）。结论是，银屑素的异常表达在人类乳腺癌中常见，且过高水平与临床结局相关。
