Emberley Ethan D, Niu Yulian, Njue Catherine, Kliewer Erich V, Murphy Leigh C, Watson Peter H
Departments of Pathology, University of Manitoba, Faculty of Medicine, Winnipeg, Manitoba, R3E OW3 Canada.
Clin Cancer Res. 2003 Jul;9(7):2627-31.
Psoriasin (S100A7) is highly expressed in preinvasive ductal carcinoma in situ of the breast and persistent expression occurs in some invasive carcinomas. This study explores the clinical significance of psoriasin in relation to patient survival in invasive breast cancer.
We examined psoriasin expression by immunohistochemistry in a cohort of 122 estrogen receptor-negative invasive ductal carcinomas.
Psoriasin expression was observed in 64 of 122 cases (52%) but was not correlated with other prognostic factors (including progesterone receptor, stage, size, grade, and nodal status) within this cohort. However, in univariate analysis, psoriasin expression (nuclear and cytoplasmic) was associated with a shorter time to progression (P < 0.04) and poor survival (P < 0.03). In multivariate analysis, cytoplasmic psoriasin also emerged as independent indicator of time to progression (hazard ratio, 1.86; 95% confidence interval, 1.02-3.39; P = 0.044) and survival (hazard ratio, 2.12; 95% confidence interval, 1.06-4.23; P = 0.033).
These results suggest that psoriasin expression may be associated with a worse prognosis in estrogen receptor-negative invasive ductal carcinomas and raise the possibility that psoriasin expression may also be an indicator of risk of progression in ductal carcinoma in situ.
牛皮癣素（S100A7）在乳腺原位导管癌的侵袭前阶段高表达，且在一些浸润性癌中持续表达。本研究探讨牛皮癣素在浸润性乳腺癌患者生存方面的临床意义。
我们通过免疫组织化学检测了122例雌激素受体阴性浸润性导管癌患者队列中的牛皮癣素表达情况。
122例病例中有64例（52%）观察到牛皮癣素表达，但在该队列中其与其他预后因素（包括孕激素受体、分期、大小、分级和淋巴结状态）无关。然而，在单因素分析中，牛皮癣素表达（核表达和胞质表达）与较短的疾病进展时间相关（P < 0.04）且与较差的生存率相关（P < 0.03）。在多因素分析中，胞质牛皮癣素也成为疾病进展时间（风险比，1.86；95%置信区间，1.02 - 3.39；P = 0.044）和生存率（风险比，2.12；95%置信区间，1.06 - 4.23；P = 0.033）的独立指标。
这些结果表明，牛皮癣素表达可能与雌激素受体阴性浸润性导管癌的预后较差相关，并增加了牛皮癣素表达也可能是原位导管癌进展风险指标的可能性。
