日本人群中谷胱甘肽S-转移酶A1和T1基因多态性的遗传分析。
Genetic analysis of glutathione S-transferase A1 and T1 polymorphisms in a Japanese population.
作者信息
Matsuno Kumi, Kubota Takahiro, Matsukura Yuji, Ishikawa Hiroshi, Iga Tatsuji
机构信息
Department of Pharmacy, Faculty of Medicine, University of Tokyo Hospital, Tokyo, Japan.
出版信息
Clin Chem Lab Med. 2004 May;42(5):560-2. doi: 10.1515/CCLM.2004.095.
Novel allelic variants have been found in the glutathione S-transferase (GST) A1 and T1 genes. The former GSTA1B allele is associated with low expression and the latter GSTT1B allele lacks GSTT1 activity. The information on frequencies of both variants is poorly documented in the Japanese population. In this study we determined the frequencies of allelic variants of GSTA1 and GSTT1 in a Japanese population using PCR-restriction fragment length polymorphism and allele-specific PCR. The frequencies of GSTA1B, GSTT10 and GSTT1*B alleles in the subjects were 16.0%, 71.1% and 0%, respectively. This is the first report on the frequencies of allelic variants of GSTA1 and GST-1 in a Japanese population.
在谷胱甘肽S-转移酶（GST）A1和T1基因中发现了新的等位基因变体。前者的GSTA1B等位基因与低表达相关，而后者的GSTT1B等位基因缺乏GSTT1活性。在日本人群中，关于这两种变体频率的信息记录很少。在本研究中，我们使用聚合酶链反应-限制性片段长度多态性和等位基因特异性聚合酶链反应，测定了日本人群中GSTA1和GSTT1等位基因变体的频率。受试者中GSTA1B、GSTT10和GSTT1*B等位基因的频率分别为16.0%、71.1%和0%。这是关于日本人群中GSTA1和GST-1等位基因变体频率的首次报道。
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