使用减毒活细菌作为异源抗原的递送系统。

The use of live attenuated bacteria as a delivery system for heterologous antigens.

作者信息

Garmory Helen S, Leary Sophie E C, Griffin Kate F, Williamson E Diane, Brown Katherine A, Titball Richard W

机构信息

Department of Biomedical Sciences, Salisbury, UK.

出版信息

J Drug Target. 2003;11(8-10):471-9. doi: 10.1080/10611860410001670008.

DOI:10.1080/10611860410001670008

PMID:15203915

Abstract

Live attenuated mutants of several pathogenic bacteria have been exploited as potential vaccine vectors for heterologous antigen delivery by the mucosal route. Such live vectors offer the advantage of potential delivery in a single oral, intranasal or inhalational dose, stimulating both systemic and mucosal immune responses. Over the years, a range of strategies have been developed to allow controlled and stable delivery of antigens and improved immunogenicity where required. Most of these approaches have been evaluated in Salmonella vaccine vectors and, as a result, several live attenuated recombinant Salmonella vaccines are now in human clinical trials. In this review, these strategies and their use in the development of a delivery system for the Yersinia pestis V antigen are described.

摘要

几种致病细菌的减毒活突变体已被用作潜在的疫苗载体，用于通过粘膜途径递送异源抗原。这种活载体的优点是可以通过单次口服、鼻内或吸入剂量进行递送，刺激全身和粘膜免疫反应。多年来，已经开发了一系列策略，以实现抗原的可控和稳定递送，并在需要时提高免疫原性。这些方法大多已在沙门氏菌疫苗载体中进行了评估，因此，几种减毒活重组沙门氏菌疫苗目前正在进行人体临床试验。在这篇综述中，将描述这些策略及其在鼠疫耶尔森氏菌V抗原递送系统开发中的应用。