将支气管败血波氏杆菌和百日咳博德特氏菌用作活疫苗及异源抗原载体。
Use of Bordetella bronchiseptica and Bordetella pertussis as live vaccines and vectors for heterologous antigens.
作者信息
Stevenson Andrew, Roberts Mark
机构信息
Molecular Bacteriology Group, Department of Veterinary Pathology, Glasgow University Veterinary School, Bearsden Road, G61 1QH, Glasgow, UK.
出版信息
FEMS Immunol Med Microbiol. 2003 Jul 15;37(2-3):121-8. doi: 10.1016/S0928-8244(03)00068-3.
Bordetella pertussis and Bordetella bronchiseptica are respiratory pathogens of humans and animals respectively. Unlike many bacteria, they are able to efficiently colonise healthy ciliated respiratory mucosa. This characteristic of Bordetella spp. can potentially be exploited to develop efficient live vaccines and vectors for delivery of heterologous antigens to the respiratory tract. Here we review the progress in this area.
百日咳博德特氏菌和支气管败血博德特氏菌分别是人类和动物的呼吸道病原体。与许多细菌不同，它们能够有效地定殖于健康的纤毛呼吸道粘膜。博德特氏菌属的这一特性有可能被用于开发高效的活疫苗和载体，以便将异源抗原递送至呼吸道。在此，我们综述该领域的进展。
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