Dabelsteen E, Clausen H, Mandel U
Department of Oral Diagnostics, School of Dentistry, University of Copenhagen, Denmark.
APMIS Suppl. 1992;27:130-8.
Cell surface carbohydrates serve as differentiation and development markers characteristic of different cell and tissue types. The expression of these carbohydrate antigens is often significantly altered in tumours, particularly in those arising from epithelial tissues. Analyses of cell surface carbohydrates in stratified epithelium have shown a remarkable variation in glycosylation pattern in relation to terminal differentiation. The carbohydrate expression is altered in squamous cell carcinomas and in premalignant lesions. There is evidence that the expression of certain carbohydrate structures in the deep invasive part of the tumours is correlated with tumour prognosis. The change in carbohydrate expression can at present be explained by the lack of synthesis of specific glycosyltransferases. New evidence suggests that the expression of certain carbohydrate structures may be importance for the formation of metastasies.
细胞表面碳水化合物作为不同细胞和组织类型特有的分化和发育标志物。这些碳水化合物抗原的表达在肿瘤中常常发生显著改变，尤其是在上皮组织来源的肿瘤中。对复层上皮细胞表面碳水化合物的分析表明，糖基化模式与终末分化存在显著差异。鳞状细胞癌和癌前病变中碳水化合物表达发生改变。有证据表明，肿瘤深部浸润部分某些碳水化合物结构的表达与肿瘤预后相关。目前，碳水化合物表达的变化可通过特定糖基转移酶合成不足来解释。新证据表明，某些碳水化合物结构的表达可能对转移灶的形成具有重要意义。
