Shiu W, Leung S F, Leung W T, Ho S, Tao M
Department of Clinical Oncology, Prince of Wales Hospital, Chinese University of Hong Kong.
Br J Cancer. 1992 Sep;66(3):555-7. doi: 10.1038/bjc.1992.313.
Serum beta-2-microglobulin (beta 2M) levels of 274 Chinese patients with different stages of nasopharyngeal carcinoma at presentation and that of 35 patients who developed distant metastases post-treatment were assayed. beta 2M level was found to increase with advancing stage of disease, with statistically significant differences among early-stage, advanced-stage, and metastatic disease. Elevated pre-treatment beta 2M levels were expressed more frequently by tumours with lower degree of histological differentiation. The sensitivity of serum beta 2M for diagnosis of nasopharyngeal carcinoma, however, is low.
检测了274例初诊时处于不同分期的中国鼻咽癌患者以及35例治疗后发生远处转移患者的血清β2-微球蛋白(β2M)水平。发现β2M水平随疾病分期进展而升高,早期、晚期和转移性疾病之间存在统计学显著差异。组织学分化程度较低的肿瘤更常表现出治疗前β2M水平升高。然而,血清β2M对鼻咽癌诊断的敏感性较低。