有效的抗逆转录病毒疗法可减少HIV - 1感染患者体内色氨酸的降解。

Effective antiretroviral therapy reduces degradation of tryptophan in patients with HIV-1 infection.

作者信息

Neurauter Gabriele, Zangerle Robert, Widner Bernhard, Quirchmair Gisela, Sarcletti Mario, Fuchs Dietmar

机构信息

Institute for Medical Chemistry and Biochemistry, University of Innsbruck, Fritz Pregl Strasse 3, A-6020 Innsbruck, Austria.

出版信息

Adv Exp Med Biol. 2003;527:317-23. doi: 10.1007/978-1-4615-0135-0_35.

DOI:10.1007/978-1-4615-0135-0_35

PMID:15206745

Abstract

Activation of indoleamine-(2,3)-dioxygenase (IDO), an enzyme converting tryptophan to N-formyl-kynurenine, was found to be critical for induction of T-cell tolerance. In 45 HIV-seropositive patients we measured plasma tryptophan and kynurenine before and 6 months post-initiation of ART. Before ART, patients had decreased tryptophan and increased kynurenine levels compared to controls. During ART, average tryptophan concentrations increased, kynurenine decreased. Tryptophan degradation correlated with neopterin levels and with viral load but not with CD4 cell counts. The data support the concept that immune activation is the common background of IDO activation and could represent an important factor underlying T-cell hyporesponsiveness in HIV infection.

摘要

吲哚胺-（2,3）-双加氧酶（IDO）可将色氨酸转化为N-甲酰犬尿氨酸，该酶的激活被发现对诱导T细胞耐受性至关重要。在45例HIV血清阳性患者中，我们在开始抗逆转录病毒治疗（ART）之前和之后6个月测量了血浆色氨酸和犬尿氨酸水平。在ART之前，与对照组相比，患者的色氨酸水平降低，犬尿氨酸水平升高。在ART期间，色氨酸平均浓度增加，犬尿氨酸减少。色氨酸降解与新蝶呤水平和病毒载量相关，但与CD4细胞计数无关。这些数据支持了免疫激活是IDO激活的共同背景这一概念，并且可能是HIV感染中T细胞低反应性的一个重要潜在因素。