Fuchs D, Möller A A, Reibnegger G, Werner E R, Werner-Felmayer G, Dierich M P, Wachter H
Institute of Medical Chemistry and Biochemistry, University of Innsbruck, Austria.
Immunol Lett. 1991 Jun;28(3):207-11. doi: 10.1016/0165-2478(91)90005-u.
Reduced tryptophan and increased kynurenine concentrations have been reported in patients with human immunodeficiency virus type 1 (HIV-1) infection. From in vitro data it appears that activated indoleamine 2,3-dioxygenase (IDO) is involved in this metabolic change. IDO is inducible by interferon-(IFN)-gamma. We compared serum concentrations of IFN-gamma and neopterin (the biosynthesis of which is also inducible by IFN-gamma) with serum, tryptophan and kynurenine of 42 patients with HIV-1 infection. IFN-gamma, neopterin and kynurenine levels were significantly increased compared to HIV-1 seronegative controls whereas tryptophan was significantly decreased. Various significant correlations were found between tryptophan, kynurenine, IFN-gamma and neopterin concentrations. Highest degree of correlation was found between neopterin, IFN-gamma and the kynurenine per tryptophan quotient which is the ratio between the product and the substrate concentration of IDO. The data indicate that decreased tryptophan in HIV-1 seropositives may result from chronic immune activation and can be referred to increased activation of IDO.
据报道，1型人类免疫缺陷病毒（HIV-1）感染患者体内色氨酸浓度降低，犬尿氨酸浓度升高。体外数据显示，活化的吲哚胺2,3-双加氧酶（IDO）参与了这种代谢变化。IDO可被γ干扰素（IFN-γ）诱导。我们比较了42例HIV-1感染患者的血清IFN-γ和新蝶呤（其生物合成也可被IFN-γ诱导）浓度与血清色氨酸和犬尿氨酸浓度。与HIV-1血清阴性对照组相比，IFN-γ、新蝶呤和犬尿氨酸水平显著升高，而色氨酸显著降低。色氨酸、犬尿氨酸、IFN-γ和新蝶呤浓度之间存在各种显著相关性。新蝶呤、IFN-γ与犬尿氨酸/色氨酸商数（即IDO的产物与底物浓度之比）之间的相关性最高。数据表明，HIV-1血清阳性患者色氨酸降低可能是慢性免疫激活所致，可归因于IDO激活增加。
