Sung Y-J, Weiler I J, Greenough W T, Denman R B
Department of Anatomy and Cell Biology Columbia University, 630 West 168th Street, New York, NY 10032, USA.
Brain Res Mol Brain Res. 2004 Jul 5;126(1):81-7. doi: 10.1016/j.molbrainres.2004.03.013.
Differential display was used to identify synapse-enriched mRNAs. Of 15 mRNAs initially identified, all were found in multiple synaptoneurosome preparations; 58% were subsequently shown to be enriched in all the preparations by Northern blotting and semiquantitative RT-PCR. RNAs involved in signal transduction, vesicle trafficking, lipid modification and cell shape and remodeling were among these messages. Tip60a mRNA, recently found to associate with the fragile X mental retardation protein, was also identified. These data demonstrate the diversity of the local message pool at synapses.
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