AMPA和NMDA受体侧向迁移率的差异活性依赖性调节。

Differential activity-dependent regulation of the lateral mobilities of AMPA and NMDA receptors.

作者信息

Groc Laurent, Heine Martin, Cognet Laurent, Brickley Kieran, Stephenson F Anne, Lounis Brahim, Choquet Daniel

机构信息

UMR 5091 CNRS-Université Bordeaux 2, Bordeaux 33077, France.

出版信息

Nat Neurosci. 2004 Jul;7(7):695-6. doi: 10.1038/nn1270. Epub 2004 Jun 20.

DOI:10.1038/nn1270

PMID:15208630

Abstract

The basis for differences in activity-dependent trafficking of AMPA receptors (AMPARs) and NMDA receptors (NMDARs) remains unclear. Using single-molecule tracking, we found different lateral mobilities for AMPARs and NMDARs: changes in neuronal activity modified AMPAR but not NMDAR mobility, whereas protein kinase C activation modified both. Differences in mobility were mainly detected for extrasynaptic AMPARs, suggesting that receptor diffusion between synaptic and extrasynaptic domains is involved in plasticity processes.

摘要

α-氨基-3-羟基-5-甲基-4-异恶唑丙酸受体（AMPARs）和N-甲基-D-天冬氨酸受体（NMDARs）活性依赖性转运差异的基础仍不清楚。通过单分子追踪，我们发现AMPARs和NMDARs具有不同的侧向迁移率：神经元活动的变化改变了AMPAR的迁移率，但未改变NMDAR的迁移率，而蛋白激酶C激活则同时改变了两者的迁移率。迁移率差异主要在突触外AMPARs中检测到，这表明突触和突触外区域之间的受体扩散参与了可塑性过程。