睡会儿觉：一种用于细菌胞质分裂空间调控的新蛋白质。

Catching some Zs: a new protein for spatial regulation of bacterial cytokinesis.

作者信息

Margolin William

机构信息

Department of Microbiology and Molecular Genetics, University of Texas Medical School, 6431 Fannin Street, Houston, Texas 77030, USA.

出版信息

Cell. 2004 Jun 25;117(7):850-1. doi: 10.1016/j.cell.2004.06.005.

DOI:10.1016/j.cell.2004.06.005

PMID:15210105

Abstract

Prior to its duplication, the bacterial nucleoid exerts local negative control over assembly of the cytokinetic Z ring to prevent potential cutting of the chromosome. In this issue of Cell, Wu and Errington show that a specific nucleoid-associated protein mediates this nucleoid occlusion effect, providing the first mechanistic insight into this key spatial regulatory system.

摘要

在细菌染色体复制之前，类核对细胞分裂Z环的组装施加局部负调控，以防止染色体被潜在切割。在本期《细胞》杂志中，吴和埃林顿表明，一种特定的类核相关蛋白介导了这种类核阻隔效应，首次为这个关键的空间调控系统提供了机制上的见解。