Racké K, Schwörer H, Simson G
Pharmakologisches Institut, Johannes Gutenberg-Universität Mainz.
Clin Investig. 1992 Mar-Apr;70(3-4):201-4. doi: 10.1007/BF00184651.
Platelets of healthy smokers and non-smokers were prepared and their content of 5-hydroxytryptamine was determined by HPLC with electrochemical detection. Platelet 5-HT levels in smokers (728 +/- 156 pmol per 10(8) platelets, mean +/- SEM, n = 9) were significantly higher than those in non-smokers (353 +/- 156 pmol per 10(8) platelets, n = 11). Smoking of a single cigarette caused a transient increase in platelet 5-HT levels by about 350% in non-smokers, but had no additional effect in smokers. Similarly, chewing of nicotine gum (4-8 mg nicotine) resulted in a transient increase in platelet 5-HT by about 100% in non-smokers, but not in smokers. In conclusion, smoking of cigarettes can cause an increase in platelet 5-HT, most likely via an enhanced supply of 5-HT from enterochromaffin cells which can be stimulated via nicotine receptors.
制备了健康吸烟者和非吸烟者的血小板，并通过带有电化学检测的高效液相色谱法测定其5-羟色胺含量。吸烟者的血小板5-羟色胺水平（每10⁸个血小板728±156皮摩尔，平均值±标准误，n = 9）显著高于非吸烟者（每10⁸个血小板353±156皮摩尔，n = 11）。吸一支香烟会使非吸烟者的血小板5-羟色胺水平短暂升高约350%，但对吸烟者没有额外影响。同样，咀嚼尼古丁口香糖（4 - 8毫克尼古丁）会使非吸烟者的血小板5-羟色胺短暂升高约100%，但对吸烟者没有这种作用。总之，吸烟会导致血小板5-羟色胺增加，最有可能是通过增强肠嗜铬细胞的5-羟色胺供应，而肠嗜铬细胞可通过尼古丁受体受到刺激。
