Harenberg J, Staiger C, de Vries J X, Weber E, Zimmermann R, Schettler G
Klin Wochenschr. 1985 Mar 1;63(5):221-4. doi: 10.1007/BF01731173.
Oral contraception as well as cigarette smoking influence haemostasis. The simultaneous effect of both on blood coagulation and fibrinolysis was studied in nine female smokers. While continuing oral contraception after a 4-week abstinence from smoking the concentration of fibrinogen, antithrombin III and alpha 1-Antitrypsin decreased (P less than 0.01 or P less than 0.04) and of plasminogen increased (P less than 0.03). The other coagulation parameters remained unchanged. Although all determinations of these parameters were in the normal range, the observed trends were statistically significant. The concentrations of the fibrinopeptide A and B 15-42 did not differ. It is concluded that the observed alteration is caused by cessation from cigarette smoking.
口服避孕药以及吸烟都会影响止血功能。我们对九名女性吸烟者同时使用口服避孕药和吸烟对血液凝固和纤维蛋白溶解的影响进行了研究。在戒烟四周后继续服用口服避孕药时，纤维蛋白原、抗凝血酶III和α1 -抗胰蛋白酶的浓度降低（P < 0.01或P < 0.04），而纤溶酶原浓度升高（P < 0.03）。其他凝血参数保持不变。尽管这些参数的所有测定值都在正常范围内，但观察到的趋势具有统计学意义。纤维肽A和B 15 - 42的浓度没有差异。得出的结论是，观察到的变化是由戒烟引起的。
