Human leukocyte antigens as genetic markers in Greek patients with sporadic pancreatic cancer.

作者信息

Kouerinis I A, Zografos G, Tarassi K E, Athanasiades T H, Liontos M, Gorgoulis V G, Korkolis D, Konstandoulakis M M, Fotiadis C I, Androulakis G, Papasteriades C A

机构信息

First Propaudeutic Surgical Department, School of Medicine, University of Athens, Greece.

出版信息

Pancreas. 2004 Jul;29(1):41-4. doi: 10.1097/00006676-200407000-00054.

DOI:10.1097/00006676-200407000-00054

PMID:15211110

Abstract

PURPOSE

In this study we investigated the relationship between specific HLA antigens and sporadic pancreatic cancer in Greek population.

METHODS

The allele frequencies of serologically and molecular defined class I and II HLA antigens were studied in 60 unrelated patients with pancreatic cancer histologically confirmed. The results obtained for HLA frequencies were compared with those of 105 healthy control subjects (control group).

RESULTS

Increased frequencies of HLA-A30 (16.7 vs. 3.8%; P < 0.01; OR = 5.05), A31 (9.5 vs. 1.9%; P < 0.05; OR = 5.72), B18 (31.7 vs. 14.3%; P < 0.05; OR = 2.78) and Cw7 (53.3 vs. 21.9%; P < 0.01; OR = 4.07) were observed in patients with pancreatic cancer in comparison to the control subjects.

CONCLUSIONS

This study demonstrates the association between specific HLA antigens and pancreatic cancer development in whites and suggests a genetic susceptibility factor for the disease.

摘要