Zammit Stanley, Jones Gaynor, Jones Susan J, Norton Nadine, Sanders Robert D, Milham Charis, McCarthy Geraldine M, Jones Lisa A, Cardno Alastair G, Gray Marion, Murphy Kieran C, O'Donovan Michael C, Owen Michael J
Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, United Kingdom.
Am J Med Genet B Neuropsychiatr Genet. 2004 Jul 1;128B(1):19-20. doi: 10.1002/ajmg.b.30021.
Some studies have reported associations between COMT and MAO genotypes and aggression, though results have been inconsistent. We examined the relationship between Overt aggression scale (OAS) scores, and both MAOA and MAOB polymorphisms in a well-powered sample of 346 subjects with schizophrenia. We also examined COMT in a Stage II replication sample of 150 individuals, and combined these results with our previously reported (Stage I) findings for COMT. We found no evidence of any associations between OAS ratings and any of the polymorphisms investigated under different genetic models. There was no evidence of epistatic interaction between MAOA and COMT on OAS scores. These results fail to support the theory that functional polymorphisms within the MAOA, MAOB, or COMT genes, as determinants of catecholamine enzymatic activity, are risk factors for aggressive behavior.
一些研究报告了儿茶酚-O-甲基转移酶（COMT）和单胺氧化酶（MAO）基因与攻击性之间的关联，尽管结果并不一致。我们在一个由346名精神分裂症患者组成的样本量充足的样本中，研究了公开攻击量表（OAS）得分与单胺氧化酶A（MAOA）和单胺氧化酶B（MAOB）多态性之间的关系。我们还在一个由150名个体组成的II期重复样本中研究了COMT，并将这些结果与我们之前报告的（I期）COMT研究结果相结合。我们没有发现任何证据表明在不同遗传模型下，OAS评分与所研究的任何多态性之间存在关联。没有证据表明MAOA和COMT在OAS得分上存在上位性相互作用。这些结果未能支持以下理论：作为儿茶酚胺酶活性决定因素的MAOA、MAOB或COMT基因内的功能性多态性是攻击行为的危险因素。
