Zhang Xinzhu, Yang Jian, Li Yuhong, Ma Xin, Li Rena
Beijing Institute for Brain Disorders, Capital Medical University, Beijing, China.
Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Beijing, China.
Oncotarget. 2017 Jan 17;8(3):3969-3979. doi: 10.18632/oncotarget.13962.
Excesses of sex chromosome abnormalities in patients with psychiatric diseases have recently been observed. It remains unclear whether sex chromosome abnormalities are related to sex differences in some psychiatric diseases. While studies showed evidence of susceptibility loci over many sex chromosomal regions related to various mental diseases, others demonstrated that the sex chromosome aneuploidies may be the key to exploring the pathogenesis of psychiatric disease. In this review, we will outline the current evidence on the interaction of sex chromosome abnormalities with schizophrenia, autism, ADHD and mood disorders.
最近观察到精神疾病患者中存在过多的性染色体异常。目前尚不清楚性染色体异常是否与某些精神疾病中的性别差异有关。虽然研究表明在许多与各种精神疾病相关的性染色体区域存在易感基因座的证据，但其他研究表明性染色体非整倍体可能是探索精神疾病发病机制的关键。在这篇综述中，我们将概述目前关于性染色体异常与精神分裂症、自闭症、注意力缺陷多动障碍和情绪障碍相互作用的证据。
