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从药物基因组学到个性化医疗:对卫生专业人员和社区进行教育的迫切需求。

From pharmacogenetics to personalized medicine: a vital need for educating health professionals and the community.

作者信息

Frueh Felix W, Gurwitz David

机构信息

Stepoutside Consulting, LLC, Gaithersburg, MD 20878, USA.

出版信息

Pharmacogenomics. 2004 Jul;5(5):571-9. doi: 10.1517/14622416.5.5.571.

Abstract

The field of pharmacogenetics will soon celebrate its 50th anniversary. Although science has delivered an impressive amount of information in these 50 years, pharmacogenetics has suffered from lack of integration into clinical practice. There are several reasons for this, including the unmet need for education at medical schools and the lack of awareness about the impact of genetic medicine on healthcare in the community. Recently, the FDA announced that it considers pharmacogenomics one of three major opportunities on the critical path to new medical products. This notion by the FDA is filling the regulatory void that existed between drug developers and drug users. However, in order to bring pharmacogenetic testing to the prescription pad successfully, healthcare professionals and policy makers, as well as patients, need to have the necessary background knowledge for making educated treatment decisions. To effectively move pharmacogenetics into everyday medicine, it is therefore imperative for scientists and teachers in the field to take on the challenge of disseminating pharmacogenetic insights to a broader audience.

摘要

药物遗传学领域即将迎来其50周年纪念日。尽管在这50年里科学已经提供了大量令人印象深刻的信息,但药物遗传学一直未能融入临床实践。造成这种情况的原因有几个,包括医学院校教育需求未得到满足,以及社区对基因医学对医疗保健影响的认识不足。最近,美国食品药品监督管理局(FDA)宣布,它将药物基因组学视为新医疗产品关键路径上的三大主要机遇之一。FDA的这一观念正在填补药物开发者和药物使用者之间存在的监管空白。然而,为了成功地将药物遗传学检测应用于处方,医疗保健专业人员、政策制定者以及患者都需要具备做出明智治疗决策所需的背景知识。因此,为了有效地将药物遗传学应用于日常医疗,该领域的科学家和教师必须承担起向更广泛受众传播药物遗传学见解的挑战。

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