Abrahams Vikki M, Kim Yeon Mee, Straszewski Shawn L, Romero Roberto, Mor Gil
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520, USA.
Am J Reprod Immunol. 2004 Apr;51(4):275-82. doi: 10.1111/j.1600-0897.2004.00156.x.
During implantation, apoptosis is critical for the appropriate tissue remodeling of the maternal decidua and invasion of the developing embryo, yet the regulation of apoptosis is also imperative for a successful pregnancy. The quick and effective removal of apoptotic cells by tissue macrophages represents an essential process, which prevents the release of self-antigens, and in the case of pregnancy, paternal alloantigens.
Recent studies have shown that the process of apoptotic cell clearance is not a neutral event, but rather an active one that induces macrophage production of anti-inflammatory cytokines and survival factors. Apoptotic cell clearance is, therefore, necessary for the resolution of inflammatory conditions, which during pregnancy could have lethal consequences.
The function of the maternal immune system during implantation and throughout pregnancy is, therefore, an important area of investigation. This review will discuss the role of decidual macrophages in apoptotic cell clearance during pregnancy.
在植入过程中，细胞凋亡对于母体蜕膜的适当组织重塑和发育中胚胎的侵入至关重要，然而细胞凋亡的调节对于成功妊娠也必不可少。组织巨噬细胞快速有效地清除凋亡细胞是一个重要过程，它可防止自身抗原的释放，在妊娠情况下还可防止父源同种异体抗原的释放。
最近的研究表明，凋亡细胞清除过程并非中性事件，而是一个诱导巨噬细胞产生抗炎细胞因子和生存因子的活跃过程。因此，凋亡细胞清除对于炎症状态的消退是必要的，而在妊娠期间这可能会产生致命后果。
因此，母体免疫系统在植入过程及整个妊娠期间的功能是一个重要的研究领域。本综述将讨论蜕膜巨噬细胞在妊娠期间凋亡细胞清除中的作用。
