长期喂食铝对大鼠脑髓鞘脂质/磷脂谱的影响。
Effect of long-term aluminum feeding on lipid/phospholipid profiles of rat brain myelin.
作者信息
Pandya Jignesh D, Dave Kunjan R, Katyare Surendra S
机构信息
Department of Biochemistry, Faculty of Science, M. S. University of Baroda, Vadodara, Gujarat 390 002, India.
出版信息
Lipids Health Dis. 2004 Jun 22;3:13. doi: 10.1186/1476-511X-3-13.
Abstract
Effect of long-term (90-100 days) exposure of rats to soluble salt of aluminum (AlCl3) on myelin lipid profile was examined. The long-term exposure to AlCl3 resulted in a 60% decrease in the total phospholipid (TPL) content while the cholesterol (CHL) content increased by 55%. Consequently the TPL/CHL molar ratio decreased significantly by 62%. The phospholipid composition of the myelin membrane changed drastically; the proportion of practically all the phospholipid classes decreased by 32 to 60% except for phosphatidylcholine (PC) and phosphatidylethanolamine (PE). Of the latter two, proportion of PC was unchanged while PE increased in proportion by 47%. Quantitatively, all phospholipid classes decreased by from 42 to 76% with no change in the PE content. However the membrane fluidity was not altered in Al-treated rats. Many of the changes we observe here show striking similarities with the reported phospholipid profiles of Alzheimer brains.
摘要
研究了大鼠长期（90 - 100天）暴露于铝的可溶性盐（AlCl3）对髓磷脂脂质谱的影响。长期暴露于AlCl3导致总磷脂（TPL）含量降低60%，而胆固醇（CHL）含量增加55%。因此，TPL/CHL摩尔比显著降低62%。髓鞘膜的磷脂组成发生了巨大变化；除磷脂酰胆碱（PC）和磷脂酰乙醇胺（PE）外，几乎所有磷脂类别的比例均下降了32%至60%。在这两种磷脂中，PC的比例不变，而PE的比例增加了47%。从数量上看，所有磷脂类别均下降了42%至76%，PE含量没有变化。然而，铝处理的大鼠的膜流动性没有改变。我们在此观察到的许多变化与报道的阿尔茨海默病大脑的磷脂谱有显著相似之处。
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