二酰甘油激酶

Diacylglycerol kinases.

作者信息

Luo Bai, Regier Debra S, Prescott Stephen M, Topham Matthew K

机构信息

The Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope, Salt Lake City, UT 84112-5550, USA.

出版信息

Cell Signal. 2004 Sep;16(9):983-9. doi: 10.1016/j.cellsig.2004.03.016.

DOI:10.1016/j.cellsig.2004.03.016

PMID:15212759

Abstract

Diacylglycerol kinases (DGKs) phosphorylate diacylglycerol to form phosphatidic acid. In most cases, members of this large family of enzymes appear to bind and regulate proteins activated by either diacylglycerol or phosphatidic acid. Proteins that appear to be regulated, in part, by DGKs include protein kinase Cs, RasGRPs, and phosphatidylinositol kinases. By modulating the activity of these proteins, DGKs potentially affect a number of biological events including-but likely not limited to-cell growth, neuronal transmission, and cytoskeleton remodeling.

摘要

二酰基甘油激酶（DGKs）将二酰基甘油磷酸化形成磷脂酸。在大多数情况下，这个大家族的酶成员似乎能结合并调节由二酰基甘油或磷脂酸激活的蛋白质。似乎部分受DGKs调节的蛋白质包括蛋白激酶C、Ras鸟苷酸释放蛋白（RasGRPs）和磷脂酰肌醇激酶。通过调节这些蛋白质的活性，DGKs可能会影响许多生物学事件，包括但可能不限于细胞生长、神经元传递和细胞骨架重塑。