Cai Jinjin, Abramovici Hanan, Gee Stephen H, Topham Matthew K
Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA.
Biochim Biophys Acta. 2009 Sep;1791(9):942-8. doi: 10.1016/j.bbalip.2009.02.010. Epub 2009 Mar 2.
There are ten mammalian diacylglycerol kinases (DGKs) whose primary role is to terminate diacylglycerol (DAG) signaling. However, it is becoming increasingly apparent that DGKs also influence signaling events through their product, phosphatidic acid (PA). They do so in some cases by associating with proteins and then modifying their activity by generating PA. In other cases, DGKs broadly regulate signaling events by virtue of their ability to provide PA for the synthesis of phosphatidylinositols (PtdIns).
有十种哺乳动物二酰基甘油激酶（DGK），其主要作用是终止二酰基甘油（DAG）信号传导。然而，越来越明显的是，DGK也通过其产物磷脂酸（PA）影响信号转导事件。在某些情况下，它们通过与蛋白质结合，然后通过生成PA来改变其活性。在其他情况下，DGK凭借其为磷脂酰肌醇（PtdIns）合成提供PA的能力，广泛调节信号转导事件。
