Wolf Henrike, Hensel Anke, Kruggel Frithjof, Riedel-Heller Steffi G, Arendt Thomas, Wahlund Lars-Olof, Gertz Hermann-Josef
Department of Psychiatry, University of Leipzig, Leipzig, Germany.
Neurobiol Aging. 2004 Aug;25(7):913-24. doi: 10.1016/j.neurobiolaging.2003.08.006.
The structural correlates of mild cognitive impairment (MCI) were examined in 105 elderly subjects whose cognitive function ranged from intact to demented, including 38 subjects with MCI. Hippocampal volumes (left and right HcV), brain volume (BV), and grey matter volume (GMV) and white matter volume (WMV) were segmented from high resolution magnetic resonance data sets and normalised to intracranial volume (ICV). Hippocampal volume reductions, but not global brain, white or grey matter atrophy, were associated with MCI. White matter lesion severity did not differ over cognitive states. In multiple logistic regression models, normalised HcV and ICV (indicating premorbid brain volume) were significant predictors of MCI versus normality. Normalised BV and ICV significantly predicted dementia versus MCI. Absolute volumetric measures of HcV and BV yielded comparable classification accuracies. Hippocampal atrophy may be the crucial step for the transition from normality to MCI. Widespread brain atrophy may be the step to determine the transition from MCI to dementia. Brain volume reserve effects appear to be involved in both of these steps.
在105名认知功能从正常到痴呆不等的老年受试者中研究了轻度认知障碍（MCI）的结构相关性，其中包括38名MCI受试者。从高分辨率磁共振数据集中分割出海马体积（左右海马体积）、脑体积（BV）、灰质体积（GMV）和白质体积（WMV），并将其标准化为颅内体积（ICV）。海马体积减小与MCI相关，但全脑、白质或灰质萎缩与MCI无关。白质病变严重程度在不同认知状态下无差异。在多元逻辑回归模型中，标准化海马体积和ICV（表明病前脑体积）是MCI与正常状态的显著预测因子。标准化BV和ICV显著预测痴呆与MCI。海马体积和BV的绝对体积测量产生了可比的分类准确率。海马萎缩可能是从正常状态转变为MCI的关键步骤。广泛的脑萎缩可能是决定从MCI转变为痴呆的步骤。脑体积储备效应似乎参与了这两个步骤。
