Pinto Francisco M, Almeida Teresa A, Hernandez Mariano, Devillier Philippe, Advenier Charles, Candenas M Luz
Instituto de Investigaciones Químicas, Centro de Investigaciones Científicas Isla de la Cartuja, CSIC, Avda. Americo Vespucio s/n, 41092 Sevilla, Spain.
Eur J Pharmacol. 2004 Jun 28;494(2-3):233-9. doi: 10.1016/j.ejphar.2004.05.016.
The tachykinins substance P, neurokinin A and neurokinin B are involved in many pathophysiological processes. A reverse transcription-polymerase chain reaction (RT-PCR) assay was used to analyse the expression of TAC1 and TAC3, the genes that encode substance P/neurokinin A and neurokinin B, respectively, and the genes encoding the tachykinin NK(1), NK(2) and NK(3) receptors in different human tissues. The data show that tachykinins and their receptors mRNAs are broadly distributed in different human tissues being present in neuronal and non-neuronal types of cells. The presence of TAC3 and the tachykinin NK(3) receptor (TACR3) in a wide variety of peripheral tissues argue for a still unexplored role of this ligand-receptor pair in mediating visceral effects of tachykinins. We found, for the first time, that TAC3 and TACR3 mRNAs are expressed in human airways and pulmonary arteries and veins, providing further evidence for the involvement of this system in lung physiopathology.
速激肽P物质、神经激肽A和神经激肽B参与许多病理生理过程。采用逆转录聚合酶链反应（RT-PCR）分析分别编码P物质/神经激肽A和神经激肽B的TAC1和TAC3基因，以及编码速激肽NK(1)、NK(2)和NK(3)受体的基因在不同人体组织中的表达。数据表明，速激肽及其受体mRNA广泛分布于不同人体组织中，存在于神经元和非神经元类型的细胞中。多种外周组织中存在TAC3和速激肽NK(3)受体（TACR3），这表明该配体-受体对在介导速激肽的内脏效应方面仍有未被探索的作用。我们首次发现，TAC3和TACR3 mRNA在人类气道以及肺动脉和肺静脉中表达，为该系统参与肺部生理病理学提供了进一步证据。
