Chu Yanhao, He Hongwen, Liu Qing, Jia Shilin, Fan Wenguo, Huang Fang
Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen Uni-versity, Guangzhou, China.
Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, China.
Cell Mol Neurobiol. 2023 Mar;43(2):511-523. doi: 10.1007/s10571-022-01205-8. Epub 2022 Feb 18.
The circadian clock is a biochemical oscillator that is synchronized with solar time. Normal circadian rhythms are necessary for many physiological functions. Circadian rhythms have also been linked with many physiological functions, several clinical symptoms, and diseases. Accumulating evidence suggests that the circadian clock appears to modulate the processing of nociceptive information. Many pain conditions display a circadian fluctuation pattern clinically. Thus, the aim of this review is to summarize the existing knowledge about the circadian clocks involved in diurnal rhythms of pain. Possible cellular and molecular mechanisms regarding the connection between the circadian clocks and pain are discussed.
生物钟是一种与太阳时间同步的生化振荡器。正常的昼夜节律对许多生理功能至关重要。昼夜节律还与许多生理功能、多种临床症状及疾病相关。越来越多的证据表明，生物钟似乎会调节伤害性信息的处理过程。许多疼痛状况在临床上呈现出昼夜波动模式。因此，本综述的目的是总结关于参与疼痛昼夜节律的生物钟的现有知识。文中还讨论了生物钟与疼痛之间联系的可能细胞和分子机制。
