百日咳毒素S1亚基C末端截短形式的表达在基于DNA的免疫后能有效诱导对百日咳毒素的保护作用。
Expression of a C terminally truncated form of pertussis toxin S1 subunit effectively induces protection against pertussis toxin following DNA-based immunization.
作者信息
Kamachi Kazunari, Arakawa Yoshichika
机构信息
Department of Bacterial Pathogenesis and Infection Control, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayma-shi, Tokyo 208-0011, Japan.
出版信息
Infect Immun. 2004 Jul;72(7):4293-6. doi: 10.1128/IAI.72.7.4293-4296.2004.
Abstract
Four plasmids encoding different C terminally and N terminally truncated pertussis toxin S1 subunits of Bordetella pertussis were constructed and tested for inducibility of protection against pertussis toxin in mice after DNA-based immunization. The region encoding an N-terminal 180-amino-acid fragment of the S1 subunit had the most potent ability to induce protective immunity.
摘要
构建了四种编码不同C端和N端截短的百日咳博德特氏菌百日咳毒素S1亚基的质粒，并在基于DNA免疫后测试了其诱导小鼠抵抗百日咳毒素的保护能力。编码S1亚基N端180个氨基酸片段的区域诱导保护性免疫的能力最强。
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