头颈部鳞状细胞癌中HOP肿瘤抑制因子表达缺失
Loss of HOP tumour suppressor expression in head and neck squamous cell carcinoma.
作者信息
Lemaire F, Millon R, Muller D, Rabouel Y, Bracco L, Abecassis J, Wasylyk B
机构信息
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/ULP, 1 Rue Laurent Fries, BP 10142, 67404 Illkirch cedex, France.
出版信息
Br J Cancer. 2004 Jul 19;91(2):258-61. doi: 10.1038/sj.bjc.6601952.
We report that homeodomain-only protein (HOP) is expressed in the suprabasal layer of normal upper aerodigestive tract epithelium and expression strongly decreases in hypopharyngeal carcinoma. Interestingly, HOP has very recently been shown to be a tumour suppressor involved in differentiation, suggesting that HOP may have a similar role in head and neck squamous cell carcinoma (HNSSC).
我们报告称，仅含同源结构域蛋白（HOP）在正常上呼吸消化道上皮的基底层上层表达，而在下咽癌中其表达显著降低。有趣的是，最近有研究表明HOP是一种参与细胞分化的肿瘤抑制因子，这表明HOP在头颈部鳞状细胞癌（HNSCC）中可能具有类似作用。
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