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孕前保健:戒烟和补充叶酸的成本及效果初步评估。

Preconception care: preliminary estimates of costs and effects of smoking cessation and folic acid supplementation.

作者信息

de Weerd Sabina, Polder Johan J, Cohen-Overbeek Titia E, Zimmermann Luc J I, Steegers Eric A P

机构信息

Department of Obstetrics and Gynecology, Erasmus Medical Center Rotterdam, The Netherlands.

出版信息

J Reprod Med. 2004 May;49(5):338-44.

Abstract

OBJECTIVE

To assess costs and effectiveness of preconception counseling for all women planning pregnancy in The Netherlands with regard to folic acid supplementation and smoking cessation counseling.

STUDY DESIGN

Costs and effects were estimated based on 200,000 women approached yearly and uptake rates of 50% and 75%. Effectiveness and potential savings were based on hospital costs of neural tube defects, low birth weight, very low birth weight and perinatal death attributable to maternal smoking.

RESULTS

Total costs were estimated at dollar 5.1 million and dollar 7.2 million at uptake rates of 50% and 75%, respectively. If 50% of women would seek preconception counseling, 22 neural tube defects, 98 low-birth-weight infants, 10 very-low-birth-weight infants and 7 perinatal deaths could be avoided. At 75% uptake, 33 neural tube defects, 146 low- and 15 very-low-birth-weight infants, and 11 perinatal deaths could be avoided.

CONCLUSION

Net costs of preconception counseling amount to dollar 3.7 million and dollar 5.0 million when considering cases prevented and subsequent potential savings in costs of neural tube defects and smoking-related morbidity only. However, in light of many other preventable adverse outcomes and the potential of preconception counseling to prevent significant lifetime costs for affected children, the net costs may ultimately result in a favorable cost-savings balance. Moreover, the importance of a healthy child cannot be expressed in terms of costs and savings alone.

摘要

目的

评估荷兰所有计划怀孕的女性在叶酸补充和戒烟咨询方面的孕前咨询成本及效果。

研究设计

根据每年接触的20万名女性以及50%和75%的接受率来估算成本和效果。效果及潜在节省基于神经管缺陷、低出生体重、极低出生体重以及因母亲吸烟导致的围产期死亡的医院成本。

结果

接受率为50%和75%时,总成本分别估计为510万美元和720万美元。如果50%的女性寻求孕前咨询,可避免22例神经管缺陷、98例低出生体重儿、10例极低出生体重儿和7例围产期死亡。接受率为75%时,可避免33例神经管缺陷、146例低出生体重儿、15例极低出生体重儿和11例围产期死亡。

结论

仅考虑预防的病例以及随后神经管缺陷和吸烟相关疾病成本的潜在节省时,孕前咨询的净成本分别为370万美元和500万美元。然而,鉴于许多其他可预防的不良后果以及孕前咨询预防受影响儿童一生重大成本的潜力,净成本最终可能带来有利的成本节省平衡。此外,健康儿童的重要性不能仅用成本和节省来衡量。

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