Wolf D, Ben-Yehuda A, Okon E, Naparstek Y
Department of Internal Medicine, Hadassah University Hospital, Jerusalem, Israel.
Cutis. 1992 Apr;49(4):253-5.
Cutaneous vasculitis is a rare complication of propylthiouracil therapy. We describe a patient who presented with lower extremity subcutaneous nodules, hemorrhagic bullae, and necrotic ulcers during treatment with this agent. Examination of a skin biopsy specimen revealed nodular vasculitis. This type of vasculitis has not been described in association with propylthiouracil therapy before. Nodular vasculitis not associated with the drug is characterized by a chronic protracted course, whereas in the patient reported the lesions rapidly regressed when use of the drug was discontinued.
皮肤血管炎是丙硫氧嘧啶治疗的一种罕见并发症。我们描述了一名在使用该药物治疗期间出现下肢皮下结节、出血性大疱和坏死性溃疡的患者。皮肤活检标本检查显示为结节性血管炎。这种类型的血管炎以前尚未见与丙硫氧嘧啶治疗相关的报道。与药物无关的结节性血管炎的特点是病程慢性迁延，而在本报告的患者中，停用该药物后病变迅速消退。
