Erem Cihangir, Yucel Yusuf, Ya Ziya, Reis Abdulkadir, Kocak Mustafa, Hacihasanoglu Arif
Division of Endocrinology and Metabolism, Department of Internal Medicine, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey.
Med Princ Pract. 2005 Sep-Oct;14(5):366-9. doi: 10.1159/000086938.
We report a case of leukocytoclastic vasculitis as a manifestation of propylthiouracil hypersensitivity.
A 66-year-old woman with a history of a toxic adenoma was referred for evaluation of a purpuric rash on the legs and buttocks bilaterally. She was biochemically hyperthyroid. Biopsy of the skin lesions revealed leukocytoclastic vasculitis. Propylthiouracil therapy was discontinued, and methimazole started. The purpuric rash resolved and surgical treatment for toxic adenoma resulted in euthyroid state.
This report indicated that leukocytoclastic vasculitis should be considered in the differential diagnosis of patients with a vasculitic rash. The discontinuation of the propylthiouracil was associated with disappearance of the lesions.
我们报告一例白细胞破碎性血管炎作为丙硫氧嘧啶超敏反应的表现。
一名66岁有毒性腺瘤病史的女性因双侧腿部和臀部紫癜性皮疹前来评估。她生化检查显示甲状腺功能亢进。皮肤病变活检显示白细胞破碎性血管炎。停用丙硫氧嘧啶治疗，开始使用甲巯咪唑。紫癜性皮疹消退，毒性腺瘤的手术治疗使甲状腺功能恢复正常。
本报告表明，在对有血管炎性皮疹的患者进行鉴别诊断时应考虑白细胞破碎性血管炎。停用丙硫氧嘧啶与病变消失有关。
