Bouman Annechien, Schipper Martin, Heineman Maas Jan, Faas Marijke M
Department of Obstetrics and Gynecology, University Hospital Groningen, Groningen, The Netherlands.
Am J Reprod Immunol. 2004 Jul;52(1):19-26. doi: 10.1111/j.1600-0897.2004.00177.x.
The purpose of this present ex vivo study is to get insight in the sex differences of the basic non-specific and specific immune response.
Intracellular types 1 and 2 cytokine production by stimulated male and female lymphocytes and monocytes in a whole blood preparation was measured by flow cytometry.
Increased percentage interleukin (IL)-12, IL-1 beta and tumor necrosis factor (TNF)-alpha producing monocytes and decreased percentage IL-2 producing lymphocytes, i.e. type 1 cytokine, were found in men as compared with women.
These results suggest a gender difference in the balance between the specific and non-specific immune response, i.e. a more profound and higher state of excitation of the non-specific immune response and relative suppression of the cellular immune response of the specific immune system in men as compared with women.
本项体外研究的目的是深入了解基本非特异性和特异性免疫反应中的性别差异。
通过流式细胞术测定全血制剂中受刺激的男性和女性淋巴细胞及单核细胞产生的1型和2型细胞内细胞因子。
与女性相比，男性中产生白细胞介素（IL）-12、IL-1β和肿瘤坏死因子（TNF）-α的单核细胞百分比增加，而产生IL-2的淋巴细胞百分比降低，即1型细胞因子。
这些结果表明，特异性和非特异性免疫反应之间的平衡存在性别差异，即与女性相比，男性非特异性免疫反应的兴奋状态更深刻、更高，而特异性免疫系统的细胞免疫反应相对受到抑制。
