Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.
State Key Laboratory of Southwestern Chinese Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
Front Immunol. 2023 Oct 4;14:1267091. doi: 10.3389/fimmu.2023.1267091. eCollection 2023.
Autoimmune diseases (AIDs) are immune disorders whose incidence and prevalence are increasing year by year. AIDs are produced by the immune system's misidentification of self-antigens, seemingly caused by excessive immune function, but in fact they are the result of reduced accuracy due to the decline in immune system function, which cannot clearly identify foreign invaders and self-antigens, thus issuing false attacks, and eventually leading to disease. The occurrence of AIDs is often accompanied by the emergence of inflammation, and inflammatory mediators (inflammatory factors, inflammasomes) play an important role in the pathogenesis of AIDs, which mediate the immune process by affecting innate cells (such as macrophages) and adaptive cells (such as T and B cells), and ultimately promote the occurrence of autoimmune responses, so targeting inflammatory mediators/pathways is one of emerging the treatment strategies of AIDs. This review will briefly describe the role of inflammation in the pathogenesis of different AIDs, and give a rough introduction to inhibitors targeting inflammatory factors, hoping to have reference significance for subsequent treatment options for AIDs.
自身免疫性疾病（AIDs）是一种免疫紊乱，其发病率和患病率逐年上升。AIDs 是由免疫系统错误识别自身抗原引起的，看似是由于免疫功能过度引起的，但实际上是由于免疫系统功能下降导致的准确性降低，无法清晰识别外来入侵者和自身抗原，从而发出虚假攻击，最终导致疾病。AIDs 的发生通常伴随着炎症的出现，炎症介质（炎症因子、炎性小体）在 AIDs 的发病机制中起着重要作用，通过影响先天细胞（如巨噬细胞）和适应性细胞（如 T 和 B 细胞）来调节免疫过程，最终促进自身免疫反应的发生，因此针对炎症介质/途径是 AIDs 新兴治疗策略之一。本文将简要描述炎症在不同 AIDs 发病机制中的作用，并对靶向炎症因子的抑制剂进行简要介绍，以期对后续 AIDs 的治疗选择具有参考意义。
