在经历自然早产或胎膜早破的女性的胎盘中，促炎细胞因子的表达增加。
Increased expression of pro-inflammatory cytokines in placentas of women undergoing spontaneous preterm delivery or premature rupture of membranes.
作者信息
El-Shazly Sherief, Makhseed Ma'asoumah, Azizieh Fawaz, Raghupathy Raj
机构信息
Department of Microbiology, Faculty of Medicine, Kuwait University, Kuwait.
出版信息
Am J Reprod Immunol. 2004 Jul;52(1):45-52. doi: 10.1111/j.1600-0897.2004.00181.x.
PROBLEM
The objective of this study was to determine the levels of cytokines in the placentas of women undergoing preterm delivery (PTD) or premature rupture of membranes (PROM) as compared with women undergoing normal delivery at term.
METHOD OF STUDY
Placentas were obtained from 30 subjects with spontaneous PTD, 30 women with PROM and 30 women with a history of normal delivery at term. Levels of interleukin (IL)-2, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha, TNF-beta, IL-4, IL-5, IL-6 and IL-10 and IL-12 were estimated by ELISA in detergent lysates of placentas from the subjects.
RESULTS
We found significantly increased levels of the Th1 cytokines IL-2 and IFN gamma and of the Th1-inducing cytokine IL-12 in placentas from the PTD and PROM groups as compared with those delivering at term. In contrast, the levels of the Th2 cytokines IL-4, IL-6 and IL-10 were significantly higher in placentas from term pregnancy.
CONCLUSIONS
These data support our observation of a pro-inflammatory cytokine bias in women with PTD and PROM.
问题
本研究的目的是确定与足月正常分娩的女性相比，早产（PTD）或胎膜早破（PROM）女性胎盘细胞因子的水平。
研究方法
从30例自然早产患者、30例胎膜早破女性和30例有足月正常分娩史的女性获取胎盘。通过酶联免疫吸附测定法（ELISA）对受试者胎盘去污剂裂解物中白细胞介素（IL）-2、干扰素（IFN）-γ、肿瘤坏死因子（TNF）-α、TNF-β、IL-4、IL-5、IL-6、IL-10和IL-12的水平进行评估。
结果
我们发现，与足月分娩的女性相比，PTD组和PROM组胎盘的Th1细胞因子IL-2和IFN-γ以及Th1诱导细胞因子IL-12水平显著升高。相反，足月妊娠胎盘的Th2细胞因子IL-4、IL-6和IL-10水平显著更高。
结论
这些数据支持我们对PTD和PROM女性促炎细胞因子偏向性的观察。
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