Fukushima Regional Center for the Japan Environment and Children's Study, 1 Hikarigaoka, Fukushima, Japan.
Department of Obstetrics and Gynecology, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima, 960-1295, Japan.
Matern Child Health J. 2024 Sep;28(9):1570-1577. doi: 10.1007/s10995-024-03950-2. Epub 2024 Jul 30.
This study aimed to evaluate the association between atopic dermatitis in pregnant women and preterm births, accounting for maternal ritodrine hydrochloride administration status.
Data of 83,796 women with singleton pregnancies at and after 22 weeks of gestation (enrolled between 2011 and 2014) were analyzed. These data were obtained from the Japan Environment and Children's Study. Atopic dermatitis was defined based on self-reported questionnaire responses obtained during the first trimester. The primary outcome measures were preterm births before 37, 32, and 28 weeks of gestation. Using a multivariable logistic regression model, odds ratios for preterm births in pregnant women with atopic dermatitis were calculated, with women without atopic dermatitis included in the reference group. This analysis considered confounding factors and maternal ritodrine hydrochloride administration.
Among pregnant women with atopic dermatitis, the adjusted odds ratios (95% confidence intervals) for preterm births before 37, 32, and 28 weeks of gestation were 0.89 (0.81-0.98), 0.98 (0.74-1.30), and 0.88 (0.50-1.55), respectively. This trend remained consistent after excluding participants who received ritodrine hydrochloride.
Atopic dermatitis in pregnant women was significantly associated with a decreased incidence of preterm births before 37 weeks of gestation, even after accounting for the effects of maternal ritodrine hydrochloride administration.
本研究旨在评估孕妇特应性皮炎与早产之间的关联，同时考虑到母亲使用盐酸利托君的情况。
对 83796 名 22 周及以上单胎妊娠的女性（2011 年至 2014 年期间入组）的数据进行了分析。这些数据来自日本环境与儿童研究。特应性皮炎是根据妊娠早期的自我报告问卷回答来定义的。主要结局指标为 37 周、32 周和 28 周前的早产。使用多变量逻辑回归模型，计算了特应性皮炎孕妇早产的比值比，以未患特应性皮炎的孕妇为参照组。该分析考虑了混杂因素和母亲使用盐酸利托君的情况。
在患有特应性皮炎的孕妇中，37 周、32 周和 28 周前早产的调整比值比（95%置信区间）分别为 0.89（0.81-0.98）、0.98（0.74-1.30）和 0.88（0.50-1.55）。在排除了使用盐酸利托君的参与者后，这一趋势仍然保持一致。
孕妇特应性皮炎与 37 周前早产的发生率显著降低相关，即使考虑到母亲使用盐酸利托君的影响也是如此。
