Cerundolo Rosario
Department of Veterinary Clinical Sciences, Faculty of Veterinary Medicine, Naples, Italy.
Vet Dermatol. 2004 Jun;15(3):181-7. doi: 10.1111/j.1365-3164.2004.00368.x.
Six Yorkshire terrier dogs with generalized, chronic dermatophytosis caused by Microsporum canis were seen over a 3-year period. Specific tests showed that they also had concurrent leishmaniosis (four cases), leishmaniosis and ehrlichiosis (one case) or diabetes mellitus (one case). Although specific therapy for these infectious diseases was instituted and the dogs were treated systemically and topically with appropriate antifungal drugs, only partial clinical resolution of the dermatophytosis was achieved. M. canis infection resolved in the dog with diabetes mellitus after stabilizing the diabetes mellitus. Although immunological studies were not performed in these cases, it is theorized that the immune disregulation caused by leishmaniosis, ehrlichiosis or diabetes mellitus may have favoured generalization of the infection and prevented favourable responses to appropriate treatment of the M. canis infection.
在三年时间里，共诊治了6只患有犬小孢子菌引起的全身性慢性皮肤真菌病的约克夏梗犬。特异性检测显示，它们还同时患有利什曼病（4例）、利什曼病和埃立克体病（1例）或糖尿病（1例）。尽管针对这些传染病采取了特异性治疗措施，并且对犬只进行了全身和局部的抗真菌药物治疗，但皮肤真菌病仅部分临床治愈。糖尿病犬在糖尿病病情稳定后，犬小孢子菌感染得到解决。尽管这些病例未进行免疫学研究，但据推测，利什曼病、埃立克体病或糖尿病引起的免疫失调可能促进了感染的扩散，并阻止了对犬小孢子菌感染进行适当治疗产生良好反应。
