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Associating protein activities with their genes: rapid identification of a gene encoding a methylglyoxal reductase in the yeast Saccharomyces cerevisiae.将蛋白质活性与其基因关联起来：快速鉴定酿酒酵母中编码甲基乙二醛还原酶的基因
Yeast. 2003 Apr 30;20(6):545-54. doi: 10.1002/yea.979.
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Genome-wide expression profile analysis reveals coordinately regulated genes associated with stepwise acquisition of azole resistance in Candida albicans clinical isolates.全基因组表达谱分析揭示了白色念珠菌临床分离株中与逐步获得唑类抗性相关的协同调控基因。
Antimicrob Agents Chemother. 2003 Apr;47(4):1220-7. doi: 10.1128/AAC.47.4.1220-1227.2003.
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Nucleoside diphosphate kinase of Saccharomyces cerevisiae, Ynk1p: localization to the mitochondrial intermembrane space.酿酒酵母的核苷二磷酸激酶Ynk1p：定位于线粒体膜间隙。
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Evaluation of differential gene expression in fluconazole-susceptible and -resistant isolates of Candida albicans by cDNA microarray analysis.通过cDNA微阵列分析评估白色念珠菌氟康唑敏感和耐药菌株中的差异基因表达。
Antimicrob Agents Chemother. 2002 Nov;46(11):3412-7. doi: 10.1128/AAC.46.11.3412-3417.2002.
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Mitochondrial DNA instability mutants of the bifunctional protein Ilv5p have altered organization in mitochondria and are targeted for degradation by Hsp78 and the Pim1p protease.
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Resistance of human fungal pathogens to antifungal drugs.人类真菌病原体对抗真菌药物的耐药性。
Curr Opin Microbiol. 2002 Aug;5(4):379-85. doi: 10.1016/s1369-5274(02)00344-2.
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Population genomics of drug resistance in Candida albicans.白色念珠菌耐药性的群体基因组学
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The genetic basis of fluconazole resistance development in Candida albicans.白色念珠菌中氟康唑耐药性产生的遗传基础。
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A common drug-responsive element mediates the upregulation of the Candida albicans ABC transporters CDR1 and CDR2, two genes involved in antifungal drug resistance.一种常见的药物反应元件介导白色念珠菌ABC转运蛋白CDR1和CDR2的上调，这两个基因与抗真菌药物耐药性有关。
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The effects of transcription regulating genes PDR1, pdr1-3 and PDR3 in pleiotropic drug resistance.转录调控基因PDR1、pdr1 - 3和PDR3在多药耐药中的作用。
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白色念珠菌临床分离株中唑类耐药性的蛋白质组学分析。

Proteomic analysis of azole resistance in Candida albicans clinical isolates.

作者信息

Hooshdaran Massoumeh Z, Barker Katherine S, Hilliard George M, Kusch Harald, Morschhäuser Joachim, Rogers P David

机构信息

Department of Pharmacy, College of Pharmacy, University of Tennessee Health Science Center, Memphis, TN 38163, USA.

出版信息

Antimicrob Agents Chemother. 2004 Jul;48(7):2733-5. doi: 10.1128/AAC.48.7.2733-2735.2004.

DOI:10.1128/AAC.48.7.2733-2735.2004
PMID:15215138
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC434221/
Abstract

Changes in protein expression within a matched set of Candida albicans isolates representing the acquisition of azole resistance were examined by two-dimensional polyacrylamide gel electrophoresis and peptide mass fingerprinting. Proteins differentially expressed in association with azole resistance included Grp2p, Ifd1p, Ifd4p, Ifd5p, and Erg10p, a protein involved in the ergosterol biosynthesis pathway.

摘要

通过二维聚丙烯酰胺凝胶电泳和肽质量指纹图谱分析，研究了一组匹配的白色念珠菌分离株中代表获得唑类抗性的蛋白质表达变化。与唑类抗性相关的差异表达蛋白质包括Grp2p、Ifd1p、Ifd4p、Ifd5p和Erg10p，后者是一种参与麦角固醇生物合成途径的蛋白质。