二氢乙烷蒽衍生物作为体外疟原虫氯喹抗性逆转剂
Dihydroethanoanthracene derivatives as in vitro malarial chloroquine resistance reversal agents.
作者信息
Millet Julie, Torrentino-Madamet Marylin, Alibert Sandrine, Rogier Christophe, Santelli-Rouvier Christiane, Mosnier Joel, Baret Eric, Barbe Jacques, Parzy Daniel, Pradines Bruno
机构信息
Unité de Parasitologie, Institut de Médecine Tropicale du Service de Santé des Armées, Boulevard Charles Livon, Parc le Pharo, BP 46, 13998 Marseille Armées, France.
出版信息
Antimicrob Agents Chemother. 2004 Jul;48(7):2753-6. doi: 10.1128/AAC.48.7.2753-2756.2004.
Abstract
The ability of four 9,10-dihydroethanoanthracene derivatives (BG920, BG932, BG958, and BG996), as well as verapamil and promethazine, to reverse chloroquine resistance was assessed against 24 chloroquine-resistant and 10 chloroquine-susceptible strains of Plasmodium falciparum from different countries. The 9,10-dihydroethanoanthracene derivatives clearly increase chloroquine susceptibility only in chloroquine-resistant isolates.
摘要
评估了四种9,10-二氢乙蒽衍生物（BG920、BG932、BG958和BG996）以及维拉帕米和异丙嗪针对来自不同国家的24株氯喹抗性恶性疟原虫和10株氯喹敏感恶性疟原虫逆转氯喹抗性的能力。9,10-二氢乙蒽衍生物仅在氯喹抗性分离株中显著增加氯喹敏感性。
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