Pradines B, Mabika Mamfoumbi M, Keundjian A, Lebeau C, Fusai T, Owono Medang M, Rogier C, Parzy D, Kombila M
Unité de parasitologie, Institut de médecine tropicale du Service de santé des armées, Marseille, France.
Bull Soc Pathol Exot. 1999 May;92(2):91-4.
The in vitro susceptibility of 91 Plasmodium falciparum isolates obtained from malaria-infected children living near Libreville (Gabon) was evaluated against chloroquine and cycloguanil (biologically active metabolite of proguanil), using an isotopic micro-drug susceptibility test. In vitro resistance to chloroquine and cycloguanil was observed in 83% (35/42) and in 38% (30/78) of the patients, respectively. Our data showed that 41% (16/39) of Gabonese field isolates were resistant both to chloroquine and cycloguanil. These findings are of great importance because they might indicate imminent chloroquine-proguanil failure, and there are not many affordable antimalarial drugs to replace chloroquine-proguanil combination.
使用同位素微量药物敏感性试验，对从利伯维尔（加蓬）附近感染疟疾的儿童中分离出的91株恶性疟原虫进行了氯喹和环氯胍（氯胍的生物活性代谢产物）的体外药敏性评估。分别在83%（35/42）和38%（30/78）的患者中观察到对氯喹和环氯胍的体外耐药性。我们的数据显示，41%（16/39）的加蓬野外分离株对氯喹和环氯胍均耐药。这些发现非常重要，因为它们可能预示着氯喹-氯胍即将失效，而且没有太多负担得起的抗疟药物来取代氯喹-氯胍组合。
