Daughaday W H
Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri.
Endocrinol Metab Clin North Am. 1992 Sep;21(3):633-47.
Pituitary gigantism is a rare condition whose association with McCune-Albright syndrome suggests that mutations in alpha-subunit of a Gs protein are an important cause of this condition. In addition to somatotroph adenoma, it is now recognized that somatotroph hyperplasia can also result from increased levels of growth hormone-releasing hormone. Transgenic rats with hypersomatotrophism are prone to renal and hepatic pathology.
垂体巨人症是一种罕见病症，其与麦库恩-奥尔布赖特综合征的关联表明，Gs蛋白α亚基的突变是该病症的一个重要病因。除生长激素细胞腺瘤外，现在还认识到生长激素释放激素水平升高也可导致生长激素细胞增生。患有生长激素分泌过多症的转基因大鼠易出现肾脏和肝脏病变。
