Bercovici J P, Mabin D, Maudelonde T, Le Mével J C, Chicault P, Mimassi N, Besson G
Presse Med. 1984 Sep 15;13(31):1885-8.
Gigantism, an extremely rare condition, develops before puberty or in subjects in whom puberty is not yet completed. Hypersecretion of somatotropic hormone results in a tremendous surge in growth (our patient was 2.36 m tall). Among other clinical symptoms disabling peripheral neuropathy predominates and changes in nerve conduction velocity are not merely due to the increase in height. The increase in growth hormone concentrations combined with hypogonadotrophic hypogonadism with normal prolactinaemia is associated with peculiar cutaneous symptoms and with low levels of sex hormone-binding protein.
巨人症是一种极为罕见的病症，在青春期前或青春期尚未结束的个体中发病。生长激素分泌过多导致生长急剧加速（我们的患者身高达2.36米）。在其他临床症状中，致残性周围神经病变较为突出，神经传导速度的改变不仅仅是由于身高增加所致。生长激素浓度升高，伴有促性腺激素缺乏性性腺功能减退及泌乳素血症正常，这与特殊的皮肤症状以及低水平的性激素结合蛋白有关。
