Boise Linda, Neal Margaret B, Kaye Jeffrey
Layton Aging and Alzheimer Disease Research Center, Oregon Health and Science University, 3181 SW Sam Jackson Park Rd., Portland, OR 97201, USA.
J Gerontol A Biol Sci Med Sci. 2004 Jun;59(6):M621-6. doi: 10.1093/gerona/59.6.m621.
Prior research has found that dementia is often undiagnosed in primary care, but there has been limited research on whether physicians respond to symptoms, behaviors, or other events that may be indicators of dementia.
A cross-sectional cohort study design was used to screen 553 patients aged 75 years or older for dementia in 3 managed health care systems in Portland, Oregon. For participants determined to be cognitively impaired, their medical charts were reviewed to determine if they had experienced adverse events, had been clinically evaluated for possible dementia, had received a diagnosis of dementia, or had been offered treatment.
Nearly 43% of participants were identified as cognitively impaired: 29.7% were classified as mildly cognitively impaired (MI) and 13.7% as moderately to severely cognitively impaired (MSI). Eighteen percent of the MI group and 34.8% of the MSI group had evidence in their medical chart of having been clinically evaluated for dementia. None of the MI group and only 4.3% of the MSI group had been offered a cholinesterase inhibitor. Nearly two thirds (61.6%) of the MI and three fourths (75.4%) of the MSI participants had experienced 1 or more adverse events. Of those who had experienced adverse events, less than one quarter (23.7%) in the MI group and less than one half (44.2%) in the MSI group had received a clinical evaluation for dementia.
These findings suggest the need for greater attention by primary care physicians to the cognitive functioning of older patients, especially patients who experience adverse events that may be indicators of dementia.
先前的研究发现,痴呆症在初级保健中常常未被诊断出来,但对于医生是否会对可能是痴呆症指标的症状、行为或其他事件做出反应的研究却很有限。
采用横断面队列研究设计,对俄勒冈州波特兰市3个管理式医疗保健系统中的553名75岁及以上的患者进行痴呆症筛查。对于被确定为认知受损的参与者,审查他们的病历,以确定他们是否经历过不良事件、是否接受过痴呆症的临床评估、是否被诊断为痴呆症或是否接受过治疗。
近43%的参与者被确定为认知受损:29.7%被分类为轻度认知受损(MCI),13.7%为中度至重度认知受损(MSI)。MCI组中有18%、MSI组中有34.8%的病历中有接受痴呆症临床评估的证据。MCI组中无人、MSI组中仅有4.3%的人接受过胆碱酯酶抑制剂治疗。近三分之二(61.6%)的MCI参与者和四分之三(75.4%)的MSI参与者经历过1次或更多次不良事件。在经历过不良事件的人中,MCI组中不到四分之一(23.7%)、MSI组中不到一半(44.2%)的人接受过痴呆症的临床评估。
这些发现表明,初级保健医生需要更加关注老年患者的认知功能,尤其是那些经历过可能是痴呆症指标的不良事件的患者。