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高频刺激可在终纹床核背外侧的谷氨酸能突触处诱导乙醇敏感的长时程增强。

High-frequency stimulation induces ethanol-sensitive long-term potentiation at glutamatergic synapses in the dorsolateral bed nucleus of the stria terminalis.

作者信息

Weitlauf Carl, Egli Regula E, Grueter Brad A, Winder Danny G

机构信息

Neuroscience Graduate Program, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0615, USA.

出版信息

J Neurosci. 2004 Jun 23;24(25):5741-7. doi: 10.1523/JNEUROSCI.1181-04.2004.

DOI:10.1523/JNEUROSCI.1181-04.2004
PMID:15215296
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6729219/
Abstract

Anatomical and functional data support a critical role for the bed nucleus of the stria terminalis (BNST) in the interaction between stress and alcohol/substance abuse. We report here that neurons of the dorsal anterolateral BNST respond to glutamatergic synaptic input in a synchronized way, such that an interpretable extracellular synaptic field potential can be readily measured. High-frequency stimulation of these glutamatergic inputs evoked NMDA receptor (NMDAR)-dependent long-term potentiation (LTP). We found that an early portion of this LTP is reduced by acute exposure to ethanol in a GABA(A) receptor-dependent manner. This effect of ethanol is accompanied by a significant and reversible dose-dependent attenuation of isolated NMDAR signaling and is mimicked by incomplete NMDAR blockade.

摘要

解剖学和功能数据支持终纹床核（BNST）在应激与酒精/药物滥用相互作用中起关键作用。我们在此报告，背外侧前BNST的神经元以同步方式对谷氨酸能突触输入作出反应，从而可以很容易地测量到可解释的细胞外突触场电位。对这些谷氨酸能输入的高频刺激诱发了NMDA受体（NMDAR）依赖性长时程增强（LTP）。我们发现，急性暴露于乙醇以GABA(A)受体依赖性方式降低了该LTP的早期部分。乙醇的这种作用伴随着分离的NMDAR信号的显著且可逆的剂量依赖性衰减，并且不完全NMDAR阻断可模拟这种作用。

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J Neurosci. 2004 Feb 18;24(7):1594-603. doi: 10.1523/JNEUROSCI.5077-03.2004.
2
Organization of axonal projections from the anterolateral area of the bed nuclei of the stria terminalis.终纹床核前外侧区轴突投射的组织架构
J Comp Neurol. 2004 Jan 6;468(2):277-98. doi: 10.1002/cne.10949.
3
Ethanol enhances alpha 4 beta 3 delta and alpha 6 beta 3 delta gamma-aminobutyric acid type A receptors at low concentrations known to affect humans.乙醇在已知会影响人类的低浓度下会增强α4β3δ和α6β3δγ-氨基丁酸A型受体。
Proc Natl Acad Sci U S A. 2003 Dec 9;100(25):15218-23. doi: 10.1073/pnas.2435171100. Epub 2003 Nov 18.
4
Stress and plasticity in the limbic system.边缘系统中的应激与可塑性。
Neurochem Res. 2003 Nov;28(11):1735-42. doi: 10.1023/a:1026021307833.
5
Ethanol modulation of excitatory and inhibitory synaptic transmission in rat and monkey dentate granule neurons.乙醇对大鼠和猴齿状颗粒神经元兴奋性和抑制性突触传递的调节作用。
Alcohol Clin Exp Res. 2003 Oct;27(10):1632-9. doi: 10.1097/01.ALC.0000089956.43262.17.
6
Exposure to acute stress blocks the induction of long-term potentiation of the amygdala-prefrontal cortex pathway in vivo.暴露于急性应激会在体内阻断杏仁核-前额叶皮层通路的长期增强效应的诱导。
J Neurosci. 2003 Jun 1;23(11):4406-9. doi: 10.1523/JNEUROSCI.23-11-04406.2003.
7
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8
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9
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