Oshchepkov D Y, Vityaev E E, Grigorovich D A, Ignatieva E V, Khlebodarova T M
Institute of Cytology and Genetics SB RAS, Novosibirsk 630090, Russia.
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W208-12. doi: 10.1093/nar/gkh474.
The local DNA conformation in the region of transcription factor binding sites, determined by context, is one of the factors underlying the specificity of DNA-protein interactions. Analysis of the local conformation of a set of functional DNA sequences may allow for determination of the conservative conformational and physicochemical parameters reflecting molecular mechanisms of interaction. The web resource SITECON is designed to detect conservative conformational and physicochemical properties in transcription factor binding sites, contains a knowledge base of conservative properties for >100 high-quality sample sites and allows for recognition of potential transcription factor binding sites based on conservative properties from both the knowledge base and the results of analysis of a sample proposed by a user. The resource SITECON is available at http://wwwmgs.bionet.nsc.ru/mgs/programs/sitecon/.
由上下文决定的转录因子结合位点区域的局部DNA构象，是DNA-蛋白质相互作用特异性的潜在因素之一。对一组功能性DNA序列序列的局部构象进行分析，可能有助于确定反映相互作用分子机制的保守构象和物理化学参数。网络资源SITECON旨在检测转录因子结合位点中的保守构象和物理化学性质，包含100多个高质量样本位点的保守性质知识库，并允许根据知识库中的保守性质以及用户提出的样本分析结果识别潜在的转录因子结合位点。可通过http://wwwmgs.bionet.nsc.ru/mgs/programs/sitecon/获取资源SITECON。
