PredictRegulon：用于预测原核生物基因组中调控蛋白结合位点和操纵子的网络服务器。
PredictRegulon: a web server for the prediction of the regulatory protein binding sites and operons in prokaryote genomes.
作者信息
Yellaboina Sailu, Seshadri Jayashree, Kumar M Senthil, Ranjan Akash
机构信息
Computational & Functional Genomics Group, Centre for DNA Fingerprinting and Diagnostics, EMBnet India Node, Hyderabad 500076, India.
出版信息
Nucleic Acids Res. 2004 Jul 1;32(Web Server issue):W318-20. doi: 10.1093/nar/gkh364.
Abstract
An interactive web server is developed for predicting the potential binding sites and its target operons for a given regulatory protein in prokaryotic genomes. The program allows users to submit known or experimentally determined binding sites of a regulatory protein as ungapped multiple sequence alignments. It analyses the upstream regions of all genes in a user-selected prokaryote genome and returns the potential binding sites along with the downstream co-regulated genes (operons). The known binding sites of a regulatory protein can also be used to identify its orthologue binding sites in phylogeneticaly related genomes where the trans-acting regulator protein and cognate cis-acting DNA sequences could be conserved. PredictRegulon can be freely accessed from a link on our world wide web server: http://www.cdfd.org.in/predictregulon/.
摘要
开发了一个交互式网络服务器，用于预测原核生物基因组中给定调控蛋白的潜在结合位点及其靶操纵子。该程序允许用户提交作为无间隙多序列比对的调控蛋白的已知或实验确定的结合位点。它分析用户选择的原核生物基因组中所有基因的上游区域，并返回潜在的结合位点以及下游共调控基因（操纵子）。调控蛋白的已知结合位点也可用于在系统发育相关基因组中识别其直系同源结合位点，其中反式作用调节蛋白和同源顺式作用DNA序列可能是保守的。可通过我们万维网服务器上的链接免费访问PredictRegulon：http://www.cdfd.org.in/predictregulon/ 。
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